[HTML][HTML] The human papillomavirus type 16 E6 and E7 oncoproteins dissociate cellular telomerase activity from the maintenance of telomere length
H Stöppler, DP Hartmann, L Sherman… - Journal of Biological …, 1997 - ASBMB
The" high risk" subgroup of human papillomaviruses (eg HPV-16 and HPV-18) infect and
induce tumors of mucosal epithelium. These neoplasms, which can progress to malignancy,
retain and express the papillomavirus E6 andE7 oncogenes. In vitro, the E6 and E7 proteins
associate with the cellular p53 and Rb proteins and interfere with their normal growth-
regulatory functions. We report here that primary human keratinocytes transduced with the
HPV-16 E6 gene, but not the E7 gene, express significant telomerase activity. However …
induce tumors of mucosal epithelium. These neoplasms, which can progress to malignancy,
retain and express the papillomavirus E6 andE7 oncogenes. In vitro, the E6 and E7 proteins
associate with the cellular p53 and Rb proteins and interfere with their normal growth-
regulatory functions. We report here that primary human keratinocytes transduced with the
HPV-16 E6 gene, but not the E7 gene, express significant telomerase activity. However …