[HTML][HTML] BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38
A Ulsamer, MJ Ortuño, S Ruiz, ARG Susperregui… - Journal of Biological …, 2008 - ASBMB
Osterix, a zinc-finger transcription factor, is specifically expressed in osteoblasts and
osteocytes of all developing bones. Because no bone formation occurs in Osterix null mice,
Osterix is thought to be an essential regulator of osteoblast differentiation. We report that
bone morphogenetic protein-2 (BMP-2) induces an increase in Osterix expression, which is
mediated through a homeodomain sequence located in the proximal region of the Osterix
promoter. Our results demonstrate that induction of Dlx5 by BMP-2 mediates Osterix …
osteocytes of all developing bones. Because no bone formation occurs in Osterix null mice,
Osterix is thought to be an essential regulator of osteoblast differentiation. We report that
bone morphogenetic protein-2 (BMP-2) induces an increase in Osterix expression, which is
mediated through a homeodomain sequence located in the proximal region of the Osterix
promoter. Our results demonstrate that induction of Dlx5 by BMP-2 mediates Osterix …