[HTML][HTML] Notch signaling and ERK activation are important for the osteomimetic properties of prostate cancer bone metastatic cell lines
M Zayzafoon, SA Abdulkadir, JM McDonald - Journal of Biological …, 2004 - ASBMB
Prostate cancer bone metastases are characterized by their ability to induce osteoblastic
lesions and local bone formation. It has been suggested that bone metastatic prostate
cancer cells are osteomimetic and capable of expressing genes and proteins typically
expressed by osteoblasts. The ability of preosteoblasts to differentiate and express
osteoblastic genes depends on several pathways, including Notch and MAPK. Here we
show that notch1 expression is increased 4-5 times in C4-2B and MDA PCa 2b cells …
lesions and local bone formation. It has been suggested that bone metastatic prostate
cancer cells are osteomimetic and capable of expressing genes and proteins typically
expressed by osteoblasts. The ability of preosteoblasts to differentiate and express
osteoblastic genes depends on several pathways, including Notch and MAPK. Here we
show that notch1 expression is increased 4-5 times in C4-2B and MDA PCa 2b cells …