[HTML][HTML] Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt …
M Qiao, P Shapiro, R Kumar, A Passaniti - Journal of Biological Chemistry, 2004 - ASBMB
Insulin-like growth factor-1 (IGF-1) is an angiogenic and oncogenic factor that activates
signal transduction pathways involved in the expression of transcriptional regulators of
tumorigenesis. RUNX2, a member of the Ig-loop family of transcription factors is expressed
in vascular endothelial cells (EC) and regulates EC migration, invasion, and proliferation.
Here we show that IGF-1 and its receptor regulate post-translational changes in RUNX2 to
activate DNA binding in proliferating EC. The phosphatidylinositol 3-kinase (PI3K) inhibitor …
signal transduction pathways involved in the expression of transcriptional regulators of
tumorigenesis. RUNX2, a member of the Ig-loop family of transcription factors is expressed
in vascular endothelial cells (EC) and regulates EC migration, invasion, and proliferation.
Here we show that IGF-1 and its receptor regulate post-translational changes in RUNX2 to
activate DNA binding in proliferating EC. The phosphatidylinositol 3-kinase (PI3K) inhibitor …