[HTML][HTML] Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
H Enslen, J Raingeaud, RJ Davis - Journal of Biological Chemistry, 1998 - ASBMB
The cellular response to treatment with proinflammatory cytokines or exposure to
environmental stress is mediated, in part, by the p38 group of mitogen-activated protein
(MAP) kinases. We report the molecular cloning of a novel isoform of p38 MAP kinase,
p38β2. This p38 MAP kinase, like p38α, is inhibited by the pyridinyl imidazole drug
SB203580. The p38 MAP kinase kinase MKK6 is identified as a common activator of p38α,
p38β2, and p38γ MAP kinase isoforms, while MKK3 activates only p38α and p38γ MAP …
environmental stress is mediated, in part, by the p38 group of mitogen-activated protein
(MAP) kinases. We report the molecular cloning of a novel isoform of p38 MAP kinase,
p38β2. This p38 MAP kinase, like p38α, is inhibited by the pyridinyl imidazole drug
SB203580. The p38 MAP kinase kinase MKK6 is identified as a common activator of p38α,
p38β2, and p38γ MAP kinase isoforms, while MKK3 activates only p38α and p38γ MAP …