Furin at the cutting edge: from protein traffic to embryogenesis and disease
G Thomas - Nature reviews Molecular cell biology, 2002 - nature.com
G Thomas
Nature reviews Molecular cell biology, 2002•nature.comFurin catalyses a simple biochemical reaction—the proteolytic maturation of proprotein
substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and
important roles in homeostasis, as well as in diseases ranging from Alzheimer's disease and
cancer to anthrax and Ebola fever. This review summarizes various features of furin—its
structural and enzymatic properties, intracellular localization, trafficking, substrates, and
roles in vivo.
substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and
important roles in homeostasis, as well as in diseases ranging from Alzheimer's disease and
cancer to anthrax and Ebola fever. This review summarizes various features of furin—its
structural and enzymatic properties, intracellular localization, trafficking, substrates, and
roles in vivo.
Abstract
Furin catalyses a simple biochemical reaction — the proteolytic maturation of proprotein substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and important roles in homeostasis, as well as in diseases ranging from Alzheimer's disease and cancer to anthrax and Ebola fever. This review summarizes various features of furin — its structural and enzymatic properties, intracellular localization, trafficking, substrates, and roles in vivo.
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