Oral inoculation of sheep with the agent of bovine spongiform encephalopathy (BSE). 1. Onset and distribution of disease-specific PrP accumulation in brain and …
M Jeffrey, S Ryder, S Martin, SAC Hawkins… - Journal of Comparative …, 2001 - Elsevier
Sixty-three Romney sheep aged 6 months, consisting of three groups (PrPARQ/ARQ,
PrPARQ/ARR, and PrPARR/ARRgenotypes) of 21 animals, were infected orally with brain
tissue from BSE-infected cattle. Sub-groups of the 21 PrPARQ/ARQanimals were killed,
together with uninfected controls 4, 10, 16, 22 or 24–28 (after the development of full clinical
disease) months post-inoculation (mpi). One sheep from each of the two groups of four killed
at 4 or 10 mpi were shown by immunohistochemical examination to possess disease …
PrPARQ/ARR, and PrPARR/ARRgenotypes) of 21 animals, were infected orally with brain
tissue from BSE-infected cattle. Sub-groups of the 21 PrPARQ/ARQanimals were killed,
together with uninfected controls 4, 10, 16, 22 or 24–28 (after the development of full clinical
disease) months post-inoculation (mpi). One sheep from each of the two groups of four killed
at 4 or 10 mpi were shown by immunohistochemical examination to possess disease …