Atypical PrPsc distribution in goats naturally affected with scrapie
G Sofianidis, V Psychas, C Billinis, V Spyrou… - Journal of comparative …, 2008 - Elsevier
The brain and spinal cord of 48 goats from two Greek herds in which scrapie had been
reported were examined. All animals were symptomless at the time of euthanasia. Notably,
no lesions were observed either at the level of the obex or at other regions of the brain and
spinal cord. Immunohistochemical examination revealed PrPsc labelling of the linear and
fine punctuate types, mainly in the cerebral cortices, of 36 goats. Twenty-seven of them were
negative by ELISA (designed to detect proteinase-resistant PrP) at the level of the obex but …
reported were examined. All animals were symptomless at the time of euthanasia. Notably,
no lesions were observed either at the level of the obex or at other regions of the brain and
spinal cord. Immunohistochemical examination revealed PrPsc labelling of the linear and
fine punctuate types, mainly in the cerebral cortices, of 36 goats. Twenty-seven of them were
negative by ELISA (designed to detect proteinase-resistant PrP) at the level of the obex but …