The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
P Angel, M Karin - Biochimica et Biophysica Acta (BBA)-Reviews on …, 1991 - Elsevier
P Angel, M Karin
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1991•ElsevierActivator protein-1 (AP-1) was first identified as a transcriptional factor that binds to an
essential cis-ele-ment of the human metallothionein lla (hMTIla) promoter [1]. AP-1 is
required for optimal basal activity of the hMTlla promoter in vivo [2-4] and in vitro [1].
Abbreviations: AP-1, activating protein 1; CRE, cAMP-responsive element; CREB, CRE
binding protein; GR, glucocorticoid receptor; GRE, glucocorticoid responsive elemet~ t; PKC,
protein kinase C; RA, retinoic acid; RAFt., retinoic acid receptor; TGF/3, transforming growth …
essential cis-ele-ment of the human metallothionein lla (hMTIla) promoter [1]. AP-1 is
required for optimal basal activity of the hMTlla promoter in vivo [2-4] and in vitro [1].
Abbreviations: AP-1, activating protein 1; CRE, cAMP-responsive element; CREB, CRE
binding protein; GR, glucocorticoid receptor; GRE, glucocorticoid responsive elemet~ t; PKC,
protein kinase C; RA, retinoic acid; RAFt., retinoic acid receptor; TGF/3, transforming growth …
Activator protein-1 (AP-1) was first identified as a transcriptional factor that binds to an essential cis-ele-ment of the human metallothionein lla (hMTIla) promoter [1]. AP-1 is required for optimal basal activity of the hMTlla promoter in vivo [2-4] and in vitro [1].
Abbreviations: AP-1, activating protein 1; CRE, cAMP-responsive element; CREB, CRE binding protein; GR, glucocorticoid receptor; GRE, glucocorticoid responsive elemet~ t; PKC, protein kinase C; RA, retinoic acid; RAFt., retinoic acid receptor; TGF/3, transforming growth factor/3; TNFa, tumor necrosis factor a; TPA, 12-O-tetradecanoylphorbol 13-acetate; TRE, TPA responsive element; UV, ultraviolet light; 1L2, interleukin.
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