[HTML][HTML] Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration
JC Sandquist, KI Swenson, KA DeMali… - Journal of Biological …, 2006 - ASBMB
The actin-myosin cytoskeleton is generally accepted to produce the contractile forces
necessary for cellular processes such as cell rounding and migration. All vertebrates
examined to date are known to express at least two isoforms of non-muscle myosin II,
referred to as myosin IIA and myosin IIB. Studies of myosin IIA and IIB in cultured cells and
null mice suggest that these isoforms perform distinct functions. However, how each myosin
II isoform contributes individually to all the cellular functions attributed to" myosin II" has yet …
necessary for cellular processes such as cell rounding and migration. All vertebrates
examined to date are known to express at least two isoforms of non-muscle myosin II,
referred to as myosin IIA and myosin IIB. Studies of myosin IIA and IIB in cultured cells and
null mice suggest that these isoforms perform distinct functions. However, how each myosin
II isoform contributes individually to all the cellular functions attributed to" myosin II" has yet …