[HTML][HTML] Endotoxin-induced myeloid-derived suppressor cells inhibit alloimmune responses via heme oxygenase-1
V De Wilde, N Van Rompaey, M Hill, JF Lebrun… - American Journal of …, 2009 - Elsevier
Inflammation and cancer are associated with impairment of T-cell responses by a
heterogeneous population of myeloid-derived suppressor cells (MDSCs) coexpressing
CD11b and GR-1 antigens. MDSCs have been recently implicated in costimulation blockade-
induced transplantation tolerance in rats, which was under the control of inducible NO
synthase (iNOS). Herein, we describe CD11b+ GR-1+ MDSC-compatible cells appearing
after repetitive injections of lipopolysaccharide (LPS) using a unique mechanism of …
heterogeneous population of myeloid-derived suppressor cells (MDSCs) coexpressing
CD11b and GR-1 antigens. MDSCs have been recently implicated in costimulation blockade-
induced transplantation tolerance in rats, which was under the control of inducible NO
synthase (iNOS). Herein, we describe CD11b+ GR-1+ MDSC-compatible cells appearing
after repetitive injections of lipopolysaccharide (LPS) using a unique mechanism of …