[HTML][HTML] Gβγ-mediated prostacyclin production and cAMP-dependent protein kinase activation by endothelin-1 promotes vascular smooth muscle cell hypertrophy …
S Taurin, K Hogarth, N Sandbo, DM Yau… - Journal of Biological …, 2007 - ASBMB
Endothelin-1 (ET1) is a vasoactive peptide that stimulates hypertrophy of vascular smooth
muscle cells (VSMC) through diverse signaling pathways mediated by G q/G i/G 13
heterotrimeric G proteins. We have found that ET1 stimulates the activity of cAMP-dependent
protein kinase (PKA) in VSMC as profoundly as the G s-linked β-adrenergic agonist,
isoproterenol (ISO), but in a transient manner. PKA activation by ET1 was mediated by type-
A ET1 receptors (ETA) and recruited an autocrine signaling mechanism distinct from that of …
muscle cells (VSMC) through diverse signaling pathways mediated by G q/G i/G 13
heterotrimeric G proteins. We have found that ET1 stimulates the activity of cAMP-dependent
protein kinase (PKA) in VSMC as profoundly as the G s-linked β-adrenergic agonist,
isoproterenol (ISO), but in a transient manner. PKA activation by ET1 was mediated by type-
A ET1 receptors (ETA) and recruited an autocrine signaling mechanism distinct from that of …