[HTML][HTML] Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression
H Kaneto, G Xu, N Fujii, S Kim, S Bonner-Weir… - Journal of Biological …, 2002 - ASBMB
Oxidative stress, which is found in pancreatic β-cells in the diabetic state, suppresses insulin
gene transcription and secretion, but the signaling pathways involved in the β-cell
dysfunction induced by oxidative stress remain unknown. In this study, subjecting rat islets to
oxidative stress activates JNK, p38 MAPK, and protein kinase C, preceding the decrease of
insulin gene expression. Adenovirus-mediated overexpression of dominant-negative type
(DN) JNK, but not the p38 MAPK inhibitor SB203580 nor the protein kinase C inhibitor …
gene transcription and secretion, but the signaling pathways involved in the β-cell
dysfunction induced by oxidative stress remain unknown. In this study, subjecting rat islets to
oxidative stress activates JNK, p38 MAPK, and protein kinase C, preceding the decrease of
insulin gene expression. Adenovirus-mediated overexpression of dominant-negative type
(DN) JNK, but not the p38 MAPK inhibitor SB203580 nor the protein kinase C inhibitor …