[HTML][HTML] ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2
PT Tarr, PA Edwards - Journal of lipid research, 2008 - ASBMB
Here, we describe the initial characterization of Abcg4−/− mice and identify overlapping
functions of ABCG4 and ABCG1 in the brain. Histological examination of tissues from
Abcg4+/−/nlsLacZ and Abcg1+/−/nlsLacZ mice demonstrates that coexpression of Abcg4
and Abcg1 is restricted to neurons and astrocytes of the central nervous system (CNS).
Interestingly, Abcg4 mRNA is undetectable outside the CNS, in contrast with the broad
tissue and cellular expression of Abcg1. We also used primary astrocytes, microglia …
functions of ABCG4 and ABCG1 in the brain. Histological examination of tissues from
Abcg4+/−/nlsLacZ and Abcg1+/−/nlsLacZ mice demonstrates that coexpression of Abcg4
and Abcg1 is restricted to neurons and astrocytes of the central nervous system (CNS).
Interestingly, Abcg4 mRNA is undetectable outside the CNS, in contrast with the broad
tissue and cellular expression of Abcg1. We also used primary astrocytes, microglia …