[HTML][HTML] Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration
A Das, ME Fernandez-Zapico, S Cao, J Yao… - Journal of biological …, 2006 - ASBMB
The farnesoid X receptor (FXR) signaling pathway regulates bile acid and cholesterol
homeostasis. Here, we demonstrate, using a variety of gain-and loss-of-function
approaches, a role of FXR in the process of cell motility, which involves the small
heterodimeric partner (SHP)-dependent up-regulation of matrix metalloproteinase-9. We use
this observation to reveal a transcriptional regulatory mechanism involving the SP/KLF
transcription factors, SP2 and KLF6. Small interference RNA-based silencing studies in …
homeostasis. Here, we demonstrate, using a variety of gain-and loss-of-function
approaches, a role of FXR in the process of cell motility, which involves the small
heterodimeric partner (SHP)-dependent up-regulation of matrix metalloproteinase-9. We use
this observation to reveal a transcriptional regulatory mechanism involving the SP/KLF
transcription factors, SP2 and KLF6. Small interference RNA-based silencing studies in …