[HTML][HTML] Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1
C Prahst, M Héroult, AA Lanahan, N Uziel… - Journal of biological …, 2008 - ASBMB
Vascular endothelial growth factor (VEGF) acts as a hierarchically high switch of the
angiogenic cascade by interacting with its high affinity VEGF receptors and with neuropilin
co-receptors. VEGF 165 binds to both Neuropilin-1 (NP-1) and VEGFR-2, and it is believed
that ligand binding forms an extracellular bridge between both molecules. This leads to
complex formation, thereby enhancing VEGFR-2 phosphorylation and subsequent
signaling. We found that inhibition of VEGF receptor (VEGFR) phosphorylation reduced …
angiogenic cascade by interacting with its high affinity VEGF receptors and with neuropilin
co-receptors. VEGF 165 binds to both Neuropilin-1 (NP-1) and VEGFR-2, and it is believed
that ligand binding forms an extracellular bridge between both molecules. This leads to
complex formation, thereby enhancing VEGFR-2 phosphorylation and subsequent
signaling. We found that inhibition of VEGF receptor (VEGFR) phosphorylation reduced …