Jet lag: therapeutic use of melatonin and possible application of melatonin analogs

V Srinivasan, DW Spence, SR Pandi-Perumal… - Travel medicine and …, 2008 - Elsevier
Each year millions of travelers undertake long distance flights over one or more continents.
These multiple time zone flights produce a constellation of symptoms known as jet lag.
Familiar to almost every intercontinental traveler is the experience of fatigue upon arrival in a
new time zone, but almost as problematic are a number of other jet lag symptoms. These
include reduced alertness, nighttime insomnia, loss of appetite, depressed mood, poor
psychomotor coordination and reduced cognitive skills, all symptoms which are closely …