Ontogeny of the type 2 glucocorticoid receptor in discrete rat brain regions: an immunocytochemical study
P Rosenfeld, JAM Van Eekelen, S Levine… - Developmental Brain …, 1988 - Elsevier
The ontogeny of the Type 2 glucocorticoid receptor (GR) in the rat brain was examined using
a monoclonal antibody raised against the rat liver GR. Marked changes both in the intensity
and in the localization of GR immunoreactivity (GR—ir) were found to occur as a function of
age and brain area examined. First, GR-ir was high perinatally and decreased to a low
intensity of immunostaining around postnatal day 12 (pnd 12). Thereafter, GR-ir increased to
a moderate intensity, which resembled adult levels by pnd 20 in most brain areas. Second …
a monoclonal antibody raised against the rat liver GR. Marked changes both in the intensity
and in the localization of GR immunoreactivity (GR—ir) were found to occur as a function of
age and brain area examined. First, GR-ir was high perinatally and decreased to a low
intensity of immunostaining around postnatal day 12 (pnd 12). Thereafter, GR-ir increased to
a moderate intensity, which resembled adult levels by pnd 20 in most brain areas. Second …