Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation
A Yaromina, M Krause, H Thames, A Rosner… - Radiotherapy and …, 2007 - Elsevier
OBJECTIVE: The response of tumours to fractionated radiotherapy is determined by many
factors including repopulation, reoxygenation, the number of clonogenic cells, and their
intrinsic radiosensitivity. However, after single radiation doses given under conditions of
clamp hypoxia, the dose to control a tumour locally is dependent only on the number of
clonogenic cells and their cellular radiosensitivity. Therefore, these parameters were
investigated using local control after single doses given under hypoxia, to predict the …
factors including repopulation, reoxygenation, the number of clonogenic cells, and their
intrinsic radiosensitivity. However, after single radiation doses given under conditions of
clamp hypoxia, the dose to control a tumour locally is dependent only on the number of
clonogenic cells and their cellular radiosensitivity. Therefore, these parameters were
investigated using local control after single doses given under hypoxia, to predict the …