[HTML][HTML] Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis in 3T3-L1 adipocytes
AMP-activated protein kinase (AMPK) is a phylogenetically conserved intracellular energy
sensor that has been implicated as a major regulator of glucose and lipid metabolism in
mammals. However, its possible role in mediating or influencing the adrenergic control of
lipolysis in adipocytes remains uncertain. In this study, we utilized the murine cultured
preadipocyte line 3T3-L1 to examine this question. Treatment of adipocytes with
isoproterenol or forskolin promoted the phosphorylation of AMPK at a critical activating Thr …
sensor that has been implicated as a major regulator of glucose and lipid metabolism in
mammals. However, its possible role in mediating or influencing the adrenergic control of
lipolysis in adipocytes remains uncertain. In this study, we utilized the murine cultured
preadipocyte line 3T3-L1 to examine this question. Treatment of adipocytes with
isoproterenol or forskolin promoted the phosphorylation of AMPK at a critical activating Thr …