[HTML][HTML] AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3β and thereby reduces cAMP-responsive element …
N Horike, H Sakoda, A Kushiyama, H Ono… - Journal of Biological …, 2008 - ASBMB
AMP-activated protein kinase (AMPK) activation reportedly suppresses transcriptional
activity of the cAMP-responsive element (CRE) in the phosphoenolpyruvate carboxykinase
C (PEPCK-C) promoter and reduces hepatic PEPCK-C expression. Although a previous
study found TORC2 phosphorylation to be involved in the suppression of AMPK-mediated
CRE transcriptional activity, we herein present evidence that glycogen synthase kinase 3β
(GSK3β) phosphorylation induced by AMPK also plays an important role. We initially found …
activity of the cAMP-responsive element (CRE) in the phosphoenolpyruvate carboxykinase
C (PEPCK-C) promoter and reduces hepatic PEPCK-C expression. Although a previous
study found TORC2 phosphorylation to be involved in the suppression of AMPK-mediated
CRE transcriptional activity, we herein present evidence that glycogen synthase kinase 3β
(GSK3β) phosphorylation induced by AMPK also plays an important role. We initially found …
