Estrogen replacement in menopausal women: recent and current prospective studies, the WHI and the KEEPS

SM Harman - Gender medicine, 2006 - Elsevier
In the wake of the Women's Health Initiative (WHI) trials, many questions have yet to be
resolved regarding the use of hormone replacement therapy (HRT) in postmenopausal
women, primarily whether HRT's cardioprotective effects outweigh a possible increase in
breast cancer risk. Several factors, including differences in HRT regimens, the duration of
follow-up, and study participants' ages, may have contributed to the widely different
conclusions of the WHI trials in comparison to the observational studies. A woman's risk of …