Blast crisis of chronic granulocytic leukemia: Morphologic variants and therapeutic implications
S Rosenthal, GP Canellos, J Whang-Peng… - The American journal of …, 1977 - Elsevier
Chronic granulocytic leukemia (CGL) terminates in a disease similar to acute leukemia.
Except for a study indicating an increased response rate to the drugs, vincristine and
prednisone, therapy of this terminal phase has been universally disappointing. We have
studied the bone marrows and clinical courses of 67 patients in the terminal phase of CGL to
discern if any parameters were associated with an increased response rate or survival. The
results of this study indicate that patients who have a lymphoblastic morphology or …
Except for a study indicating an increased response rate to the drugs, vincristine and
prednisone, therapy of this terminal phase has been universally disappointing. We have
studied the bone marrows and clinical courses of 67 patients in the terminal phase of CGL to
discern if any parameters were associated with an increased response rate or survival. The
results of this study indicate that patients who have a lymphoblastic morphology or …