Additional clonal abnormalities in Philadelphia-positive ALL and CML demonstrate a different cytogenetic pattern at diagnosis and follow different pathways at …
U Bacher, T Haferlach, W Hiddemann… - Cancer genetics and …, 2005 - Elsevier
The cytogenetic patterns in addition to the Philadelphia translocation in Philadelphia-
positive (Ph+) ALL and chronic myeloid leukemia (CML) is heterogenous. We investigated
154 patients with Ph+ ALL at diagnosis or at relapse and 174 patients with different phases
of CML. Ph+ ALL at diagnosis demonstrated a heterogenous pattern with a high frequency
of numerical and structural chromosomal aberrations. CML at diagnosis presented with rare
additional chromosomal changes. In Ph+ ALL, the pathway from diagnosis to relapse was …
positive (Ph+) ALL and chronic myeloid leukemia (CML) is heterogenous. We investigated
154 patients with Ph+ ALL at diagnosis or at relapse and 174 patients with different phases
of CML. Ph+ ALL at diagnosis demonstrated a heterogenous pattern with a high frequency
of numerical and structural chromosomal aberrations. CML at diagnosis presented with rare
additional chromosomal changes. In Ph+ ALL, the pathway from diagnosis to relapse was …