The kinase inhibitor STI571 reverses the Bcr–Abl induced point mutation frequencies observed in pre-leukemic P190Bcr–Abl transgenic mice
JM Brain, A Saksena, P Laneuville - Leukemia Research, 2002 - Elsevier
Chronic myelogenous leukemia (CML) and 25% of adult onset acute lymphoblastic
leukemia (ALL) are associated with the expression of Bcr–Abl, a constitutively activated
protein tyrosine kinase. Bcr–Abl associated leukemias are characterized by a high degree of
chromosomal and genomic instability. It is unclear if the phenotype of genomic instability is a
primary consequence of Bcr–Abl expression or if it is acquired secondarily. We have
attempted to answer this question in previous studies by measuring the frequency of point …
leukemia (ALL) are associated with the expression of Bcr–Abl, a constitutively activated
protein tyrosine kinase. Bcr–Abl associated leukemias are characterized by a high degree of
chromosomal and genomic instability. It is unclear if the phenotype of genomic instability is a
primary consequence of Bcr–Abl expression or if it is acquired secondarily. We have
attempted to answer this question in previous studies by measuring the frequency of point …