Magnetic resonance imaging detects differences in migration between primary and immortalized neural stem cells

S Magnitsky, RM Walton, JH Wolfe, H Poptani - Academic radiology, 2008 - Elsevier
RATIONALE AND OBJECTIVES: The study was performed to evaluate the effect of magnetic
resonance imaging (MRI) contrast agent (super paramagnetic iron oxide [SPIO]) on
differentiation and migration of primary murine neural stem cells (NSCs) in comparison to a
neural stem cell line (C17. 2). Because detection of labeled cells depends on the
concentration of SPIO particles per imaging voxel, the study was performed at various
concentrations of SPIO particles to determine the concentration that could be used for in vivo …