[HTML][HTML] Pten, tumorigenesis, and stem cell self-renewal
DJ Rossi, IL Weissman - Cell, 2006 - cell.com
DJ Rossi, IL Weissman
Cell, 2006•cell.comSelf-renewal pathways crucial for maintaining stem cells are deregulated in cancer, raising
the spectre that cancer therapies targeting such pathways might also ablate normal stem
cells. As Yilmaz et al.(2006) report in a recent Nature paper, this may not be the case for the
tumor suppressor protein Pten, which drives the self-renewal of normal hematopoietic stem
cells and the formation of leukemia cells through different mechanisms.
the spectre that cancer therapies targeting such pathways might also ablate normal stem
cells. As Yilmaz et al.(2006) report in a recent Nature paper, this may not be the case for the
tumor suppressor protein Pten, which drives the self-renewal of normal hematopoietic stem
cells and the formation of leukemia cells through different mechanisms.
Self-renewal pathways crucial for maintaining stem cells are deregulated in cancer, raising the spectre that cancer therapies targeting such pathways might also ablate normal stem cells. As Yilmaz et al. (2006) report in a recent Nature paper, this may not be the case for the tumor suppressor protein Pten, which drives the self-renewal of normal hematopoietic stem cells and the formation of leukemia cells through different mechanisms.
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