[HTML][HTML] MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival
YL Yu, YJ Chiang, YC Chen, M Papetti, CG Juo… - Journal of Biological …, 2005 - ASBMB
In the interleukin 3-dependent hematopoietic cell line Ba/F3, inhibition of mitogen-activated
protein kinase, a member of the MAPK/c-Jun N-terminal kinase/stress-activated protein
kinase kinase family that plays an important role in cell growth and death control, rapidly
leads to severe apoptosis. However, most of the antiapoptotic substrates of MAPK remain to
be identified. Here we report that, upon interleukin-3 stimulation of Ba/F3 cells, the
transcription factor GATA-1 is strongly phosphorylated at residue serine 26 by a MAPK …
protein kinase, a member of the MAPK/c-Jun N-terminal kinase/stress-activated protein
kinase kinase family that plays an important role in cell growth and death control, rapidly
leads to severe apoptosis. However, most of the antiapoptotic substrates of MAPK remain to
be identified. Here we report that, upon interleukin-3 stimulation of Ba/F3 cells, the
transcription factor GATA-1 is strongly phosphorylated at residue serine 26 by a MAPK …