Cell cycle control by the thyroid hormone in neuroblastoma cells
S Garcia-Silva, G Perez-Juste, A Aranda - Toxicology, 2002 - Elsevier
The thyroid hormone (T3) blocks proliferation and induces differentiation of neuroblastoma
N2a-β cells that overexpress the β1 isoform of the T3 receptor. An element in the region
responsible for premature termination of transcription mediates a rapid repression of c-myc
gene expression by T3. The hormone also causes a decrease of cyclin D1 gene
transcription, and is able to antagonize the activation of the cyclin D1 promoter by Ras. In
addition, a strong and sustained increase of the levels of the cyclin kinase inhibitor (CKI) …
N2a-β cells that overexpress the β1 isoform of the T3 receptor. An element in the region
responsible for premature termination of transcription mediates a rapid repression of c-myc
gene expression by T3. The hormone also causes a decrease of cyclin D1 gene
transcription, and is able to antagonize the activation of the cyclin D1 promoter by Ras. In
addition, a strong and sustained increase of the levels of the cyclin kinase inhibitor (CKI) …