[HTML][HTML] Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining
B Sis, GS Jhangri, S Bunnag, K Allanach… - American Journal of …, 2009 - Elsevier
Anti-HLA alloantibody is a risk factor for graft loss, but does not indicate which kidneys are
experiencing antibody-mediated rejection (ABMR). C4d staining in biopsies is specific for
ABMR but insensitive. We hypothesized that altered expression of endothelial genes due to
alloantibody acting on the microcirculation would be sensitive indicator of ABMR. We
identified 119 endothelial-associated transcripts (ENDATs) from literature, and studied their
expression by microarrays in 173 renal allograft biopsies for cause. Mean ENDAT …
experiencing antibody-mediated rejection (ABMR). C4d staining in biopsies is specific for
ABMR but insensitive. We hypothesized that altered expression of endothelial genes due to
alloantibody acting on the microcirculation would be sensitive indicator of ABMR. We
identified 119 endothelial-associated transcripts (ENDATs) from literature, and studied their
expression by microarrays in 173 renal allograft biopsies for cause. Mean ENDAT …