[HTML][HTML] Changes in the transcriptome in allograft rejection: IFN-γ-induced transcripts in mouse kidney allografts
KS Famulski, G Eineckea, J Reeve, V Ramassar… - American journal of …, 2006 - Elsevier
We used Affymetrix Microarrays to define interferon-γ (IFN-γ)-dependent, rejection-induced
transcripts (GRITs) in mouse kidney allografts. The algorithm included inducibility by
recombinant IFN-γ in kidneys of three normal mouse strains, increase in kidney allografts in
three strain combinations and less induction in IFN-γ-deficient allografts. We identified 40
transcripts, which were highly IFN-γ inducible (eg Cxcl9, ubiquitin D, MHC), and 168 less
sensitive to IFN-γ in normal kidney. In allografts, expression of GRITs was intense and …
transcripts (GRITs) in mouse kidney allografts. The algorithm included inducibility by
recombinant IFN-γ in kidneys of three normal mouse strains, increase in kidney allografts in
three strain combinations and less induction in IFN-γ-deficient allografts. We identified 40
transcripts, which were highly IFN-γ inducible (eg Cxcl9, ubiquitin D, MHC), and 168 less
sensitive to IFN-γ in normal kidney. In allografts, expression of GRITs was intense and …