Publisher Summary This chapter provides an overview of receptor activation from
biochemical and cellular studies regarding immune system development and function when
various components of the Interleukin-2-receptor (IL-2R) signal are disrupted. The biologic
effects of IL-2R signals are much more complex than simply mediating T-cell growth, and
depending upon the set of conditions, IL-2R signals may also promote cell survival, effector
function, and apoptosis. These sometimes contradictory effects underscore the fact that a …