[HTML][HTML] Cyclin-dependent kinase 5 (Cdk5) activation domain of neuronal Cdk5 activator: Evidence of the existence of cyclin fold in neuronal Cdk5a activator
Neuronal Cdk5 activator (Nck5a) differs from other cyclin-dependent kinase (Cdk) activators
in that its amino acid sequence is only marginally similar to the cyclin consensus sequence.
Nevertheless, computer modeling has suggested that Nck5a contains the cyclin-fold motif
recently identified in the crystal structure of cyclin A. In the present study, a number of
truncation mutants and substitution mutants of the Nck5a were produced and tested for the
Cdk5 activation and Cdk5 binding activity. The active domain of Nck5a determined by using …
in that its amino acid sequence is only marginally similar to the cyclin consensus sequence.
Nevertheless, computer modeling has suggested that Nck5a contains the cyclin-fold motif
recently identified in the crystal structure of cyclin A. In the present study, a number of
truncation mutants and substitution mutants of the Nck5a were produced and tested for the
Cdk5 activation and Cdk5 binding activity. The active domain of Nck5a determined by using …