[HTML][HTML] PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes
X Tang, AM Powelka, NA Soriano, MP Czech… - Journal of Biological …, 2005 - ASBMB
Glucose homeostasis is controlled by insulin in part through the stimulation of glucose
transport in muscle and fat cells. This insulin signaling pathway requires
phosphatidylinositol (PI) 3-kinase-mediated 3′-polyphosphoinositide generation and
activation of Akt/protein kinase B. Previous experiments using dominant negative constructs
and gene ablation in mice suggested that two phosphoinositide phosphatases, SH2 domain-
containing inositol 5′-phosphatase 2 (SHIP2) and phosphatase and tensin homolog …
transport in muscle and fat cells. This insulin signaling pathway requires
phosphatidylinositol (PI) 3-kinase-mediated 3′-polyphosphoinositide generation and
activation of Akt/protein kinase B. Previous experiments using dominant negative constructs
and gene ablation in mice suggested that two phosphoinositide phosphatases, SH2 domain-
containing inositol 5′-phosphatase 2 (SHIP2) and phosphatase and tensin homolog …