[HTML][HTML] Overlapping, but not identical, sites are involved in the recognition of C3bi, neutrophil inhibitory factor, and adhesive ligands by the αMβ2 integrin
L Zhang, EF Plow - Journal of Biological Chemistry, 1996 - ASBMB
The α M β 2 (CD11b/CD18, Mac-1) integrin receptor binds numerous ligands, including
neutrophil inhibitory factor (NIF), C3bi, and certain immobilized protein substrates,
represented by denatured ovalbumin. These ligands share no obvious structural similarities,
yet their interactions with receptor are inhibited by NIF and involve the I domain, a stretch
of∼ 200 amino acids in the α M subunit. Recombinant wild-type and mutant forms of α M β 2
have been used to compare the recognition requirements of these ligands. The various …
neutrophil inhibitory factor (NIF), C3bi, and certain immobilized protein substrates,
represented by denatured ovalbumin. These ligands share no obvious structural similarities,
yet their interactions with receptor are inhibited by NIF and involve the I domain, a stretch
of∼ 200 amino acids in the α M subunit. Recombinant wild-type and mutant forms of α M β 2
have been used to compare the recognition requirements of these ligands. The various …