[PDF][PDF] Collateral damage from antigen receptor gene diversification
GK Mahowald, JM Baron, BP Sleckman - Cell, 2008 - cell.com
GK Mahowald, JM Baron, BP Sleckman
Cell, 2008•cell.comChromosomal translocations that juxtapose antigen receptor genes and oncogenes are
frequently associated with lymphoid malignancies. In this issue, Robbiani et al.(2008) show
that activation-induced deaminase (AID), an enzyme involved in antigen receptor gene
diversification, generates DNA double-strand breaks (DSBs) in oncogenes, and Tsai et
al.(2008) propose that AID and the recombinase-activating gene (RAG) endonuclease may
collaborate to generate off-target DSBs.
frequently associated with lymphoid malignancies. In this issue, Robbiani et al.(2008) show
that activation-induced deaminase (AID), an enzyme involved in antigen receptor gene
diversification, generates DNA double-strand breaks (DSBs) in oncogenes, and Tsai et
al.(2008) propose that AID and the recombinase-activating gene (RAG) endonuclease may
collaborate to generate off-target DSBs.
Chromosomal translocations that juxtapose antigen receptor genes and oncogenes are frequently associated with lymphoid malignancies. In this issue, Robbiani et al. (2008) show that activation-induced deaminase (AID), an enzyme involved in antigen receptor gene diversification, generates DNA double-strand breaks (DSBs) in oncogenes, and Tsai et al. (2008) propose that AID and the recombinase-activating gene (RAG) endonuclease may collaborate to generate off-target DSBs.
cell.com