Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation
T Koshiba, Y Li, M Takemura, Y Wu, S Sakaguchi… - Transplant …, 2007 - Elsevier
In the setting of our pediatric living-donor liver transplantation (LDLT), 87 patients (15.0% of
all the patients: significantly higher proportion, compared with those of other transplant
centers) achieved complete withdrawal of immunosuppression, which is referred to as
“operational tolerance”. Immunosuppressants were completely discontinued for 54 patients
as scheduled, and for 33 because of EBV infection or other complications. Immunological
analyses of the peripheral blood derived from operationally tolerant patients demonstrated …
all the patients: significantly higher proportion, compared with those of other transplant
centers) achieved complete withdrawal of immunosuppression, which is referred to as
“operational tolerance”. Immunosuppressants were completely discontinued for 54 patients
as scheduled, and for 33 because of EBV infection or other complications. Immunological
analyses of the peripheral blood derived from operationally tolerant patients demonstrated …