[HTML][HTML] MITF and PU. 1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation

SM Sharma, A Bronisz, R Hu, K Patel… - Journal of Biological …, 2007 - ASBMB
Transcription factors NFATc1, PU. 1, and MITF collaborate to regulate specific genes in
response to colony-stimulating factor-1 (CSF-1) and receptor activator of NF-κB ligand
(RANKL) signaling during osteoclast differentiation. However, molecular details concerning
timing and mechanism of specific events remain ill-defined. In bone marrow-derived
precursors, CSF-1 alone promoted assembly of MITF-PU. 1 complexes at osteoclast target
gene promoters like cathepsin K and acid 5 phosphatase without increasing gene …