[HTML][HTML] Hypusine is required for a sequence-specific interaction of eukaryotic initiation factor 5A with postsystematic evolution of ligands by exponential enrichment …
A Xu, KY Chen - Journal of Biological Chemistry, 2001 - ASBMB
Hypusine is formed through a spermidine-dependent posttranslational modification of
eukaryotic initiation factor 5A (eIF-5A) at a specific lysine residue. The reaction is catalyzed
by deoxyhypusine synthase and deoxyhypusine hydroxylase. eIF-5A is the only protein in
eukaryotes and archaebacteria known to contain hypusine. Although both eIF-5A and
deoxyhypusine synthase are essential genes for cell survival and proliferation, the precise
biological function of eIF-5A is unclear. We have previously proposed that eIF-5A may …
eukaryotic initiation factor 5A (eIF-5A) at a specific lysine residue. The reaction is catalyzed
by deoxyhypusine synthase and deoxyhypusine hydroxylase. eIF-5A is the only protein in
eukaryotes and archaebacteria known to contain hypusine. Although both eIF-5A and
deoxyhypusine synthase are essential genes for cell survival and proliferation, the precise
biological function of eIF-5A is unclear. We have previously proposed that eIF-5A may …