CXCL10 regulates liver innate immune response against ischemia and reperfusion injury
Y Zhai, XD Shen, F Gao, A Zhao, MC Freitas… - Hepatology, 2008 - journals.lww.com
We have shown that activation of toll-like receptor 4 (TLR4) and its interferon regulatory
factor 3 (IRF3)-dependent downstream signaling pathway are required for the development
of liver ischemia/reperfusion injury (IRI). This study focused on the role of TLR4-IRF3
activation pathway products, in particular, chemokine (CXC motif) ligand 10 (CXCL10). The
induction of CXCL10 by liver IR was rapid (1 hour postreperfusion), restricted (ischemic
lobes), and specific (no CXCL9 and CXCL11 induction). Functionally, CXCL10 was critical …
factor 3 (IRF3)-dependent downstream signaling pathway are required for the development
of liver ischemia/reperfusion injury (IRI). This study focused on the role of TLR4-IRF3
activation pathway products, in particular, chemokine (CXC motif) ligand 10 (CXCL10). The
induction of CXCL10 by liver IR was rapid (1 hour postreperfusion), restricted (ischemic
lobes), and specific (no CXCL9 and CXCL11 induction). Functionally, CXCL10 was critical …