[HTML][HTML] CXCR3 and heparin binding sites of the chemokine IP-10 (CXCL10)
GSV Campanella, EMJ Lee, J Sun, AD Luster - Journal of biological …, 2003 - ASBMB
The chemokine IP-10 (interferon-inducible protein of 10 kDa, CXCL10) binds the G protein-
coupled receptor CXCR3, which is found mainly on activated T cells and NK cells, and plays
an important role in Th1-type inflammatory diseases. IP-10 also binds to
glycosaminoglycans (GAGs), an interaction thought to be important for its sequestration on
endothelial and other cells. In this study, we performed an extensive mutational analysis to
identify the CXCR3 and heparin binding sites of murine IP-10. The mutants were …
coupled receptor CXCR3, which is found mainly on activated T cells and NK cells, and plays
an important role in Th1-type inflammatory diseases. IP-10 also binds to
glycosaminoglycans (GAGs), an interaction thought to be important for its sequestration on
endothelial and other cells. In this study, we performed an extensive mutational analysis to
identify the CXCR3 and heparin binding sites of murine IP-10. The mutants were …
