Pancreatic endocrine microadenomatosis in patients with von Hippel-Lindau disease: characterization by VHL/HIF pathway proteins expression
P Hammel, O Corcos, O Larochelle… - The American journal …, 2009 - journals.lww.com
Methods Nontumoral pancreas of 18 VHL patients operated on for PET, was examined for
microadenomatosis (≤ 5 mm) and compared with pancreatic specimen obtained from non-
VHL patients or MEN1 patients. The immunohistochemical expression of chromogranin,
insulin, glucagon, HIF-1α, HIF-2α, VEGF, CA9, cyclin D1, and CD34 was assessed. Results
In addition to 39 macrotumors (1 to 5/patient), chromogranin-positive endocrine
microadenomas were found in 13 (72%) patients located within acini or close to ducts or …
microadenomatosis (≤ 5 mm) and compared with pancreatic specimen obtained from non-
VHL patients or MEN1 patients. The immunohistochemical expression of chromogranin,
insulin, glucagon, HIF-1α, HIF-2α, VEGF, CA9, cyclin D1, and CD34 was assessed. Results
In addition to 39 macrotumors (1 to 5/patient), chromogranin-positive endocrine
microadenomas were found in 13 (72%) patients located within acini or close to ducts or …