[HTML][HTML] Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
C Treins, S Giorgetti-Peraldi, J Murdaca… - Journal of Biological …, 2002 - ASBMB
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor involved in normal mammalian
development and in the pathogenesis of several disease states. It consists of two subunits,
HIF-1α, which is degraded during normoxia, and HIF-1β, which is constitutively expressed.
Activated HIF-1 induces the expression of genes involved in angiogenesis, erythropoiesis,
and glucose metabolism. We have previously reported that insulin stimulates vascular
endothelial growth factor (VEGF) expression (1). In this study, we show that insulin activates …
development and in the pathogenesis of several disease states. It consists of two subunits,
HIF-1α, which is degraded during normoxia, and HIF-1β, which is constitutively expressed.
Activated HIF-1 induces the expression of genes involved in angiogenesis, erythropoiesis,
and glucose metabolism. We have previously reported that insulin stimulates vascular
endothelial growth factor (VEGF) expression (1). In this study, we show that insulin activates …