Modulation of renal apical organic anion transporter 4 function by two pdz domain–containing proteins
H Miyazaki, N Anzai, S Ekaratanawong… - Journal of the …, 2005 - journals.lww.com
Human organic anion transporter 4 (OAT4) is an apical organic anion/dicarboxylate
exchanger in the renal proximal tubules and mediates high-affinity transport of steroid
sulfates such as estrone-3-sulfate (E 1 S) and dehydroepiandrosterone sulfate. Here, two
multivalent PDZ (PSD-95/Discs Large/ZO-1) proteins PDZK1 and NHERF1 were examined
as interactors of OAT4 by a yeast two-hybrid assay. These interactions require the extreme C-
terminal region of OAT4 and the first and fourth PDZ domains of PDZK1 and the first PDZ …
exchanger in the renal proximal tubules and mediates high-affinity transport of steroid
sulfates such as estrone-3-sulfate (E 1 S) and dehydroepiandrosterone sulfate. Here, two
multivalent PDZ (PSD-95/Discs Large/ZO-1) proteins PDZK1 and NHERF1 were examined
as interactors of OAT4 by a yeast two-hybrid assay. These interactions require the extreme C-
terminal region of OAT4 and the first and fourth PDZ domains of PDZK1 and the first PDZ …