[HTML][HTML] Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2
L Cupillard, K Koumanov, MG Mattéi… - Journal of Biological …, 1997 - ASBMB
Secretory phospholipases A 2 (sPLA 2 s) represent a rapidly expanding family of structurally
related enzymes found in mammals as well as in insect and snake venoms. In this report, a
cDNA coding for a novel sPLA 2 has been isolated from human fetal lung, and its gene has
been mapped to chromosome 16p13. 1-p12. The mature sPLA 2 protein has a molecular
mass of 13.6 kDa, is acidic (pI 5.3), and made up of 123 amino acids. Key structural features
of the sPLA 2 include:(i) a long prepropeptide ending with an arginine doublet,(ii) 16 …
related enzymes found in mammals as well as in insect and snake venoms. In this report, a
cDNA coding for a novel sPLA 2 has been isolated from human fetal lung, and its gene has
been mapped to chromosome 16p13. 1-p12. The mature sPLA 2 protein has a molecular
mass of 13.6 kDa, is acidic (pI 5.3), and made up of 123 amino acids. Key structural features
of the sPLA 2 include:(i) a long prepropeptide ending with an arginine doublet,(ii) 16 …