[HTML][HTML] On the diversity of secreted phospholipases A2: cloning, tissue distribution, and functional expression of two novel mouse group II enzymes
E Valentin, F Ghomashchi, MH Gelb… - Journal of Biological …, 1999 - ASBMB
Over the last decade, an expanding diversity of secreted phospholipases A 2 (sPLA 2 s) has
been identified in mammals. Here, we report the cloning in mice of three additional sPLA 2 s
called mouse group IIE (mGIIE), IIF (mGIIF), and X (mGX) sPLA 2 s, thus giving rise to eight
distinct sPLA 2 s in this species. Both mGIIE and mGIIF sPLA 2 s contain the typical
cysteines of group II sPLA 2 s, but have relatively low levels of identity (less than 51%) with
other mouse sPLA 2 s, indicating that these enzymes are novel group II sPLA 2 s. However …
been identified in mammals. Here, we report the cloning in mice of three additional sPLA 2 s
called mouse group IIE (mGIIE), IIF (mGIIF), and X (mGX) sPLA 2 s, thus giving rise to eight
distinct sPLA 2 s in this species. Both mGIIE and mGIIF sPLA 2 s contain the typical
cysteines of group II sPLA 2 s, but have relatively low levels of identity (less than 51%) with
other mouse sPLA 2 s, indicating that these enzymes are novel group II sPLA 2 s. However …