The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors

T Taniguchi, A Takaoka - Current opinion in immunology, 2002 - Elsevier
T Taniguchi, A Takaoka
Current opinion in immunology, 2002Elsevier
The efficient induction of interferons α and β (IFN-α/β) in virus-infected cells is central to the
antiviral response of a host and is regulated mainly at the level of gene transcription. Once
produced, IFN-α/β transmit signals to the cell interior via a specific receptor complex to
induce an antiviral response. Recently, the auto-amplification mechanism of the IFN-α/β
system that follows viral infection has been identified. This mechanism is mediated by
transcription factors of the IFN regulatory factor family and, in fact, may have evolved to …
The efficient induction of interferons α and β (IFN-α/β) in virus-infected cells is central to the antiviral response of a host and is regulated mainly at the level of gene transcription. Once produced, IFN-α/β transmit signals to the cell interior via a specific receptor complex to induce an antiviral response. Recently, the auto-amplification mechanism of the IFN-α/β system that follows viral infection has been identified. This mechanism is mediated by transcription factors of the IFN regulatory factor family and, in fact, may have evolved to render the system more robust in antiviral responses.
Elsevier