[HTML][HTML] The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells: involvement of death …
LH Xu, X Yang, CA Bradham, DA Brenner… - Journal of Biological …, 2000 - ASBMB
The focal adhesion kinase (FAK) is a mediator of cell-extracellular matrix signaling events
and is overexpressed in tumor cells. In order to rapidly down-regulate FAK function in
normal and transformed mammary cells, we have used adenoviral gene transduction of the
carboxyl-terminal domain of FAK (FAK-CD). Transduction of adenovirus containing FAK-CD
in breast cancer cells caused loss of adhesion, degradation of p125 FAK, and induced
apoptosis. Furthermore, breast tumor cells that were viable without matrix attachment also …
and is overexpressed in tumor cells. In order to rapidly down-regulate FAK function in
normal and transformed mammary cells, we have used adenoviral gene transduction of the
carboxyl-terminal domain of FAK (FAK-CD). Transduction of adenovirus containing FAK-CD
in breast cancer cells caused loss of adhesion, degradation of p125 FAK, and induced
apoptosis. Furthermore, breast tumor cells that were viable without matrix attachment also …