[HTML][HTML] The homeobox transcription factor Hox D3 promotes integrin α5β1 expression and function during angiogenesis
NJ Boudreau, JA Varner - Journal of Biological Chemistry, 2004 - ASBMB
Neovascularization promotes wound healing, tumor growth, and arthritis. Endothelial cell
migration and survival during neovascularization are regulated by adhesion proteins,
including integrin α 5 β 1. Integrin α 5 β 1 is poorly expressed on normal quiescent blood
vessels, but its expression is induced on tumor blood vessels and in response to angiogenic
factors such as basic fibroblast growth factor, interleukin-8, tumor necrosis factor-α, and the
angiomatrix protein Del-1. We show here that α 5 β 1 expression, and hence function, during …
migration and survival during neovascularization are regulated by adhesion proteins,
including integrin α 5 β 1. Integrin α 5 β 1 is poorly expressed on normal quiescent blood
vessels, but its expression is induced on tumor blood vessels and in response to angiogenic
factors such as basic fibroblast growth factor, interleukin-8, tumor necrosis factor-α, and the
angiomatrix protein Del-1. We show here that α 5 β 1 expression, and hence function, during …