[HTML][HTML] Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells
PA Reynolds, M Sigaroudinia, G Zardo… - Journal of Biological …, 2006 - ASBMB
Alterations in DNA methylation are important in cancer, but the acquisition of these
alterations is poorly understood. Using an unbiased global screen for CpG island
methylation events, we have identified a non-random pattern of DNA hypermethylation
acquired in p16-repressed cells. Interestingly, this pattern included loci located upstream of
a number of homeobox genes. Upon removal of p16 INK4A activity in primary human
mammary epithelial cells, polycomb repressors, EZH2 and SUZ12, are up-regulated and …
alterations is poorly understood. Using an unbiased global screen for CpG island
methylation events, we have identified a non-random pattern of DNA hypermethylation
acquired in p16-repressed cells. Interestingly, this pattern included loci located upstream of
a number of homeobox genes. Upon removal of p16 INK4A activity in primary human
mammary epithelial cells, polycomb repressors, EZH2 and SUZ12, are up-regulated and …